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Index > Protein center > STOM(Gene name) > Human
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  • STOM (Gene name),
  • Erythrocyte band 7 integral membrane protein (Protein name ),  STOM_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    STOM(BND7;EPB72);
    Protein name:
    Erythrocyte band 7 integral membrane protein;
    Alternative:
    Stomatin;Protein 7.2b;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homooligomer containing between 9 and 12 monomers. Interacts with ACCN1, ACCN2 and ACCN3 (By similarity). Interacts with LANCL1.
    Function:
    Thought to regulate cation conductance. May regulate ACCN1 and ACCN3 gating.
    Subcellular Location:
    Cell membrane Peripheral membrane protein Cytoplasmic side Cell membrane Lipid-anchor Cytoplasmic side Melanosome Exposed on the cytoplasmic surface of the membrane. Associated with lipid rafts. Concentrates preferentially in plasma membrane protrusions and in a juxta-nuclear region which may represent Golgi-derived vesicles. Colocalizes with actin. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
    Protein Attributes:
    Sequence length:
    288
    Sequence:
    50:
    MAEKRHTRDS | EAQRLPDSFK | DSPSKGLGPC | GWILVAFSFL | FTVITFPISI | 
    100:
    WMCIKIIKEY | ERAIIFRLGR | ILQGGAKGPG | LFFILPCTDS | FIKVDMRTIS | 
    150:
    FDIPPQEILT | KDSVTISVDG | VVYYRVQNAT | LAVANITNAD | SATRLLAQTT | 
    200:
    LRNVLGTKNL | SQILSDREEI | AHNMQSTLDD | ATDAWGIKVE | RVEIKDVKLP | 
    250:
    VQLQRAMAAE | AEASREARAK | VIAAEGEMNA | SRALKEASMV | ITESPAALQL | 
    288:
    RYLQTLTTIA | AEKNSTIVFP | LPIDMLQGII | GAKHSHLG
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    UniGene:
    SMR:
    Pfam:
    MIM:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Erythrocyte band 7 integral membrane protein
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    E2125m
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    ELISA Kit for Human Erythrocyte band 7 integral membrane protein
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    E2125h
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    CLIA Kit for Human Erythrocyte band 7 integral membrane protein
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    U2125m
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    Packing:
    96T
    CLIA Kit for Human Erythrocyte band 7 integral membrane protein
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    U2125h
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    Packing:
    96T
    Polyclonal Antibody for Human Erythrocyte band 7 integral membrane protein
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    P2125Rb-h
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    Packing:
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    Polyclonal Antibody for Human Erythrocyte band 7 integral membrane protein
    Cat.:
    P2125Rb-m
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Erythrocyte band 7 integral membrane protein
    Monoclonal Antibody for Human Erythrocyte band 7 integral membrane protein
    Protein for Human Erythrocyte band 7 integral membrane protein
    Protein for Human Erythrocyte band 7 integral membrane protein

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Cloning and nucleotide sequence of cDNA encoding human erythrocyte band 7 integral membrane protein."
      Hiebl-Dirschmied C.M. , Entler B. , Glotzmann C. , Maurer-Fogy I. , Stratowa C. , Prohaska R.
      Biochim. Biophys. Acta1090:123-124(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PARTIAL PROTEIN SEQUENCE
    2. 2.
      "Isolation of cDNA coding for an ubiquitous membrane protein deficient in high Na+, low K+ stomatocytic erythrocytes."
      Stewart G.W. , Hepworth-Jones B.E. , Keen J.N. , Dash B.C.J. , Argent A.C. , Casimir C.M.
      Blood79:1593-1601(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PROTEIN SEQUENCE OF 187-232;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
      tissue: Bone marrow.
    3. 3.
      "The organization of the gene (EPB72) encoding the human erythrocyte band 7 integral membrane protein (protein 7.2b)."
      Unfried I. , Entler B. , Prohaska R.
      Genomics30:521-528(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      "Structure, organization, and expression of the human band 7.2b gene, a candidate gene for hereditary hydrocytosis."
      Gallagher P.G. , Forget B.G.
      J. Biol. Chem.270:26358-26363(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    5. 5.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Halleck A. , Ebert L. , Mkoundinya M. , Schick M. , Eisenstein S. , Neubert P. , Kstrang K. , Schatten R. , Shen B. , Henze S. , Mar W. , Korn B. , Zuo D. , Hu Y. , LaBaer J.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    6. 6.
      "DNA sequence and analysis of human chromosome 9."
      Humphray S.J. , Oliver K. , Hunt A.R. , Plumb R.W. , Loveland J.E. , Howe K.L. , Andrews T.D. , Searle S. , Hunt S.E. , Scott C.E. , Jones M.C. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Ashwell R.I.S. , Babbage A.K. , Babbage S. , Bagguley C.L. , more...
      Nature429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Eye.
      tissue: Hypothalamus.
    8. 8.
      "Identification of the phosphorylation site on human erythrocyte band 7 integral membrane protein: implications for a monotopic protein structure."
      Salzer U. , Ahorn H. , Prohaska R.
      Biochim. Biophys. Acta1151:149-152(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 5-25;PHOSPHORYLATION AT SER-10
    9. 9.
      "Colocalization of stomatin (band 7.2b) and actin microfilaments in UAC epithelial cells."
      Snyers L. , Thines-Sempoux D. , Prohaska R.
      Eur. J. Cell Biol.73:281-285(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    10. 10.
      "Isolation, molecular characterization, and tissue-specific expression of a novel putative G protein-coupled receptor."
      Mayer H. , Salzer U. , Breuss J. , Ziegler S. , Marchler-Bauer A. , Prohaska R.
      Biochim. Biophys. Acta1395:301-308(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LANCL1
      tissue: Bone marrow.
      tissue: Erythrocyte.
      tissue: Fetal brain.
    11. 11.
      "Oligomeric nature of the integral membrane protein stomatin."
      Snyers L. , Umlauf E. , Prohaska R.
      J. Biol. Chem.273:17221-17226(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT
    12. 12.
      "Cysteine 29 is the major palmitoylation site on stomatin."
      Snyers L. , Umlauf E. , Prohaska R.
      FEBS Lett.449:101-104(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PALMITOYLATION AT CYS-30 AND CYS-87
    13. 13.
      "Stomatin is a major lipid-raft component of platelet alpha granules."
      Mairhofer M. , Steiner M. , Mosgoeller W. , Prohaska R. , Salzer U.
      Blood100:897-904(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    14. 14.
      "Proteomic analysis of early melanosomes: identification of novel melanosomal proteins."
      Basrur V. , Yang F. , Kushimoto T. , Higashimoto Y. , Yasumoto K. , Valencia J. , Muller J. , Vieira W.D. , Watabe H. , Shabanowitz J. , Hearing V.J. , Hunt D.F. , Appella E.
      J. Proteome Res.2:69-79(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]
      tissue: Melanoma.
    15. 15.
      "Characterization of the stomatin domain involved in homo-oligomerization and lipid raft association."
      Umlauf E. , Mairhofer M. , Prohaska R.
      J. Biol. Chem.281:23349-23356(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF THR-182; TRP-185; TYR-252 AND 263-LYS--LEU-276
    16. 16.
      "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes."
      Chi A. , Valencia J.C. , Hu Z.-Z. , Watabe H. , Yamaguchi H. , Mangini N.J. , Huang H. , Canfield V.A. , Cheng K.C. , Yang F. , Abe R. , Yamagishi S. , Shabanowitz J. , Hearing V.J. , Wu C. , Appella E. , Hunt D.F.
      J. Proteome Res.5:3135-3144(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]
      tissue: Melanoma.
    17. 17.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-244;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    18. 18.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    19. 19.
      "Stomatin interacts with GLUT1/SLC2A1, band 3/SLC4A1, and aquaporin-1 in human erythrocyte membrane domains."
      Rungaldier S. , Oberwagner W. , Salzer U. , Csaszar E. , Prohaska R.
      Biochim. Biophys. Acta1828:956-966(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY;INTERACTION WITH SLC2A1 AND SLC4A1;SUBUNIT
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